021-51111890
购物车（）
sales@molnova.cn
PF-2545920 hydrochloride
CAS No. ——
PF-2545920 hydrochloride ( Mardepodect hydrochloride;MP-10 hydrochloride;PF-02545920 hydrochloride )
产品货号. M16961 CAS No. ——
A potent and selective PDE10A inhibitor with IC50 of 0.37 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称PF-2545920 hydrochloride
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A potent and selective PDE10A inhibitor with IC50 of 0.37 nM.
-
产品描述A potent and selective PDE10A inhibitor with IC50 of 0.37 nM; displays >1,000-fold selectivity over the PDEs; antagonizes apomorphine-induced climbing in mice, inhibits conditioned avoidance responding in both rats and mice, and blocks NMDA antagonist-induced deficits in prepulse inhibition of acoustic startle response in rats; dose-dependently increases c-Fos immunopositive nuclei in all regions of neostriatum in the DRd1a-tdTomato mice; improves cortico-basal ganglia function in huntington's disease models; orally bioavailable.Schizophrenia Phase 2 Discontinued
-
同义词Mardepodect hydrochloride;MP-10 hydrochloride;PF-02545920 hydrochloride
-
通路Angiogenesis
-
靶点PDE
-
受体PDE
-
研究领域——
-
适应症——
化学信息
-
CAS Number——
-
分子量428.91
-
分子式C25H21ClN4O
-
纯度>98% (HPLC)
-
溶解度DMSO
-
SMILES——
-
化学全称Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-,hydrochloride(1:1)
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Verhoest PR, et al. J Med Chem. 2009 Aug 27;52(16):5188-96.
2. Grauer SM, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):574-90.
3. Beaumont V, et al. Neuron. 2016 Dec 21;92(6):1220-1237.
2. Grauer SM, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):574-90.
3. Beaumont V, et al. Neuron. 2016 Dec 21;92(6):1220-1237.
产品手册
关联产品
-
CHF6001
A novel, highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 0.026 nM.
-
Pimobendan
Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
-
CDP-840 hydrochlorid...
CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM.
